Chlorphentermine-induced ultrastructural changes in liver tissues of four animal species
Identifieur interne : 003B01 ( Main/Exploration ); précédent : 003B00; suivant : 003B02Chlorphentermine-induced ultrastructural changes in liver tissues of four animal species
Auteurs : R. Lüllmann-Rauch [Allemagne] ; G. H. Reil [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1973-12-01.
English descriptors
- Teeft :
- Adrenal glands, Animal species, Anorectic drug, Autophagic activity, Biochemical study, Body weights, Cell biol, Chemical composition, Chlorphentermine, Chlorphentermine treatment, Chronic administration, Concentric arrays, Cytological alterations, Cytoplasmic, Cytoplasmic vacuoles, Daems, Dense bodies, Drug treatment, Druginduced lipidosis, Endothelial cells, Fine structure, Granular appearance, Guinea, Guinea pigs, Hepatocyte, Hepatocytes, Homogenous, Hruban, Inclusion, Inclusion bodies, Internal structure, Kupffer, Kupffer cell, Kupffer cells, Lamellar, Lamellar material, Lamellated, Lamellated material, Lfillmann, Lipid, Lipid storage diseases, Lipidosis, Liver cells, Liver changes, Liver tissue, Liver tissues, Lysosome, Myeloid bodies, Numerous inclusion bodies, Opaque cytoplasmic bodies, Other cell components, Other compounds, Other species, Other tissues, Peribiliary, Peribiliary bodies, Pericanalicular bodies, Present findings, Present study, Reil, Residual bodies, Secondary lysosomes, Significant increase, Sinusoidal walls, Such inclusions, Syrian hamsters, Triparanol, Ultrastructural, Ultrastructural alterations, Ultrastructural changes, Vacuole, Various tissues, Virchows arch.
Abstract
Summary: The ultrastructure of liver tissues from guinea pigs, rabbits, mice, and rats was examined after chronic administration of the anorectic drug chlorphentermine. While hepatocytes of rats remained largely unaltered, those of guinea pigs, rabbits and mice contained numerous membrane-limited inclusion bodies with a lamellar, a reticular or a crystallinelike internal structure. Similar inclusions were found in increased numbers within Kupffer cells of rats, guinea pigs and mice. The cytological alterations are interpreted to result from an abnormal intralysosomal accumulation of phospholipids or other lipids. The findings are taken as supporting the concept of a drug-induced lipidosis.
Url:
DOI: 10.1007/BF02889316
Affiliations:
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B Zellpath.</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1973-12-01">1973-12-01</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="307">307</biblScope><biblScope unit="page" to="320">320</biblScope></imprint><idno type="ISSN">0340-6075</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adrenal glands</term><term>Animal species</term><term>Anorectic drug</term><term>Autophagic activity</term><term>Biochemical study</term><term>Body weights</term><term>Cell biol</term><term>Chemical composition</term><term>Chlorphentermine</term><term>Chlorphentermine treatment</term><term>Chronic administration</term><term>Concentric arrays</term><term>Cytological alterations</term><term>Cytoplasmic</term><term>Cytoplasmic vacuoles</term><term>Daems</term><term>Dense bodies</term><term>Drug treatment</term><term>Druginduced lipidosis</term><term>Endothelial cells</term><term>Fine structure</term><term>Granular appearance</term><term>Guinea</term><term>Guinea pigs</term><term>Hepatocyte</term><term>Hepatocytes</term><term>Homogenous</term><term>Hruban</term><term>Inclusion</term><term>Inclusion bodies</term><term>Internal structure</term><term>Kupffer</term><term>Kupffer cell</term><term>Kupffer cells</term><term>Lamellar</term><term>Lamellar material</term><term>Lamellated</term><term>Lamellated material</term><term>Lfillmann</term><term>Lipid</term><term>Lipid storage diseases</term><term>Lipidosis</term><term>Liver cells</term><term>Liver changes</term><term>Liver tissue</term><term>Liver tissues</term><term>Lysosome</term><term>Myeloid bodies</term><term>Numerous inclusion bodies</term><term>Opaque cytoplasmic bodies</term><term>Other cell components</term><term>Other compounds</term><term>Other species</term><term>Other tissues</term><term>Peribiliary</term><term>Peribiliary bodies</term><term>Pericanalicular bodies</term><term>Present findings</term><term>Present study</term><term>Reil</term><term>Residual bodies</term><term>Secondary lysosomes</term><term>Significant increase</term><term>Sinusoidal walls</term><term>Such inclusions</term><term>Syrian hamsters</term><term>Triparanol</term><term>Ultrastructural</term><term>Ultrastructural alterations</term><term>Ultrastructural changes</term><term>Vacuole</term><term>Various tissues</term><term>Virchows arch</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The ultrastructure of liver tissues from guinea pigs, rabbits, mice, and rats was examined after chronic administration of the anorectic drug chlorphentermine. While hepatocytes of rats remained largely unaltered, those of guinea pigs, rabbits and mice contained numerous membrane-limited inclusion bodies with a lamellar, a reticular or a crystallinelike internal structure. Similar inclusions were found in increased numbers within Kupffer cells of rats, guinea pigs and mice. The cytological alterations are interpreted to result from an abnormal intralysosomal accumulation of phospholipids or other lipids. The findings are taken as supporting the concept of a drug-induced lipidosis.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R." last="Lüllmann-Rauch">R. Lüllmann-Rauch</name></noRegion><name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R." last="Lüllmann-Rauch">R. Lüllmann-Rauch</name><name sortKey="Reil, G H" sort="Reil, G H" uniqKey="Reil G" first="G. H." last="Reil">G. H. Reil</name><name sortKey="Reil, G H" sort="Reil, G H" uniqKey="Reil G" first="G. H." last="Reil">G. H. Reil</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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